4-Isopropoxybenzaldehyde → HCID 59975299, compound

Participants

Reaction Steps

The title compound was prepared by a similar method to example 5 using (2R,3R,4S,5R)-2-{2-(aminomethyl)-6-[(2,2-diphenylethyl)amino}-9H-purin-9-yl}-5-(methoxymethyl)tetrahydro-3,4-furandiol (example 1) (225 mg, 0.46 mmol), sodium triacetoxyborohydnde (212 mg, 1.0 mmol) and 4-isopropoxybenzaldehyde (84 mg, 0.51 mmol) in tetrahydrofuran (15 ml). The product was purified by column chromatography on silica gel eluting with a solvent system of dichloromethane:methanol:ammonia (95:5:0.5). This gave the title compound (53 mg) as a foam. MS: 639 (MH+).

Provenance & Evidence