Tetrahydrofuran → HCID 59975337, compound

Participants

Reaction Steps

The title compound was prepared by a similar method to example 38 using N-(2-{9-[(2R,3R,4R,5R)-3,4-bis{[tert-butyl(dimethyl)silyl]oxy}-5-(methoxymethyl)tetrahydro-2-furanyl]-6-[(2,2-diphenylethyl)amino]-9H-purin-2-yl}ethyl)-N-(2-methoxyethyl)amine (150 mg, 0.19 mmol) (preparation 34) and a 1 molar solution of tetra-n-butylammonium fluoride in tetrahydrofuran (0.5 ml, 0.5 mmol). The compound was purified by column chromatography on silica gel eluting with a solvent gradient of dichloromethane:methanol:ammonia (94:6:0.6) increasing in polarity to (90:10:1) to give the title compound (50 mg) as a foam. MS: 563 (MH+).

Provenance & Evidence