Tetrahydrofuran → HCID 59975284, compound

Participants

Reaction Steps

The title compound was prepared by a similar method to example 38 using N-benzyl-N-(2-{9-[(2R,3R,4R,5R)-3,4-bis{[tert-butyl(dimethyl)silyl]oxy}-5-(methoxymethyl)tetrahydro-2-furanyl]-6-[(2,2-diphenylethyl)amino]-9H-purin-2-yl}ethyl)amine (360 mg, 0.44 mmol) (preparation 39) and a 1 molar solution of tetrabutylammonium fluoride in tetrahydrofuran (0.92 ml, 0.92 mmol). The product was purified by column chromatography on silica gel eluting with a solvent gradient of dichloromethane:methanol (93:7) increasing in polarity to dichloromethane:methanol:ammonia (90:10:1) to give the title compound (162 mg) as a foam. MS: 596 (MH+).

Provenance & Evidence