Potassium Hydroxide → HCID 23702367, compound

Participants

Reaction Steps

N-({9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(methoxymethyl)tetrahydro-2-furanyl]-6-[(2,2-diphenylethyl)amino]-9H-purin-2-yl}methyl)-2-methyl-1-propanesulfonamide (example 15) (1.9 g, 3.11 mmol) was dissolved into isopropyl alcohol (20 ml) and a 4 molar solution of potassium hydroxide (0.9 ml, 3.11 mmol) added. The isopropyl alcohol was removed by evaporation under reduced pressure and more isopropyl alcohol (20 ml) added to the residue, then the solvent removed under reduced pressure again. The residue was suspended in isopropyl alcohol (160 ml) and then the suspension heated under reflux for 1 hr. The resulting suspension was allowed to cool and then filtered. The white solid was washed with a little isopropyl alcohol and then dried. This gave the title compound (1.5 g) as a white crystalline solid m.p. 231° C.

Provenance & Evidence