HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 1-Bromo-6-bromomethyl-2,3,4,5-tetramethoxybenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 1-Bromo-2,3,4,5-tetramethoxy-6-methylbenzene | HCID 12560769 | — |
| Catalyst | Azobisisobutyronitrile | HCID 6547 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-Bromo-6-bromomethyl-2,3,4,5-tetramethoxybenzene | HCID 18348620 | 99.5% |
Reaction Steps
An ethyl acetate (300 ml) solution of 1-bromo-2,3,4,5-tetramethoxy-6-methylbenzene (49.5 g, 0.170 mols), N-bromosuccinimide (31.8 g, 0.179 mols) and AIBN (558 mg, 3.40 mmols) was heated under reflux for 1 hour. The reaction mixture was concentrated in vacuo, and then diluted with hexane. The resulting crystals were separated by filtration, and the filtrate was concentrated to obtain the entitled compound (62.6 g) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06326369B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-5e97f78620604b55a49a76458f60ea52 |
| Source note | uspto-grants-2001_12 |