反应详情

A mixture comprised of an ethanol (8 ml) solution of ethyl 8-(2-ethoxycarbonyl-4,5,6,7-tetramethoxyindan-2-yl)octanoate (367 mg, 0.764 mmols) and an aqueous sodium hydroxide solution (1N, 0.764 ml, 0.764 mmols) was stirred at room temperature for 6 hours, and an aqueous sodium hydroxide solution (1 N, 0.153 ml, 0.153 mmols) was added thereto and the stirring was continued at room temperature for further 6 hours. The reaction mixture was concentrated in vacuo, which was made acidic by adding 1 N hydrochloric acid, followed by extraction with ethyl acetate. The organic layer was washed with water and a saturated aqueous sodium chloride solution, and then dried. The solvent was evaporated out in vacuo, and the resulting crude product was purified by silica gel column chromatography (hexane:ethyl acetate=2:1 to 1:2) to obtain the entitled compound (78.6 mg) as an oil.

1. concentrationThe reaction mixture was concentrated in vacuo, which
2. additionby adding 1 N hydrochloric acid
3. extractionfollowed by extraction with ethyl acetate
4. washThe organic layer was washed with water
5. dry with materiala saturated aqueous sodium chloride solution, and then dried
6. customThe solvent was evaporated out in vacuo
7. customthe resulting crude product was purified by silica gel column chromatography (hexane:ethyl acetate=2:1 to 1:2)