反应详情

An aqueous sodium hydroxide solution (3 N, 0.440 ml, 1.32 mmols) was added to an ethanol (4 ml) solution of ethyl 2-[4-(4-ethoxycarbonyl-1-oxabutyl)phenyl]-4,5,6,7-tetramethoxy-2-indancarboxylate (342 mg, 0.662 mmols), and heated under reflux for 6 hours. The reaction mixture was concentrated in vacuo, diluted with water, made acidic by adding 10% hydrochloric acid, and then extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, and then dried. The solvent was evaporated out, and the resulting crude product was purified by recrystallization (from hexane-ethyl acetate) to obtain the entitled compound (300 mg) as crystals.

1. temperatureheated
2. temperatureunder reflux for 6 hours
3. concentrationThe reaction mixture was concentrated in vacuo
4. additiondiluted with water
5. additionby adding 10% hydrochloric acid
6. extractionextracted with ethyl acetate
7. washThe organic layer was washed with a saturated aqueous sodium chloride solution
8. customdried
9. customThe solvent was evaporated out
10. customthe resulting crude product was purified by recrystallization (from hexane-ethyl acetate)