Triethylamine → HCID 18348591, compound

Participants

Reaction Steps

A THF (16 ml) suspension of 4-[4-(4,5,6,7-tetramethoxyindan-1-yl)butoxy]benzoic acid (400 mg, 0.929 mmols), dimethylammonium chloride (150 mg, 1.86 mmols), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (357 mg, 1.86 mmols), 1-hydroxybenzotriazole monohydrate (285 mg, 1.86 mmols) and triethylamine (0.777 ml, 5.57 mmols) was stirred at room temperature for 12 hours. Water was added to the reaction mixture, which was then extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, and then dried. The solvent was evaporated out in vacuo, and the resulting crude product was purified by alumina column chromatography (ethyl acetate) followed by recrystallization (from hexane-ethyl acetate) to obtain the entitled compound (408 mg) as crystals.

Provenance & Evidence