反应详情

To a solution of 8-(4,5,6,7-tetramethoxyindan-2-yl)octanol (1.20 g) in pyridine (6.0 ml) was dropwise added anhydrous acetic acid (0.555 ml) at room temperature. After being stirred for 12 hr, the reaction mixture was concentrated in vacuo, made acidic with 1N hydrochloric acid, and extracted with ethyl acetate. The organic layer was washed with 1N hydrochloric acid, water, and saturated aqueous sodium chloride, and dried. The solvent was removed in vacuo. The resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=10:1) to yield the entitled compound (1.25 g) as crystals.

1. customat room temperature
2. concentrationthe reaction mixture was concentrated in vacuo
3. extractionextracted with ethyl acetate
4. washThe organic layer was washed with 1N hydrochloric acid, water, and saturated aqueous sodium chloride
5. customdried
6. customThe solvent was removed in vacuo
7. customThe resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=10:1)