Hydrogen Peroxide → HCID 18348570, compound

Participants

Reaction Steps

To a mixture of 8-(4,5,6,7-tetramethoxy-2-phenylindan-2-yl)octanal (985 mg), sodium dihydrogenphosphate (72.6 mg), 30% hydrogen peroxide (0.435 ml), acetonitrile (10 ml), and water (4 ml) was dropwise added a solution of sodium chlorite (80%, 355 mg) in water (14 ml) with cooling with ice in 30 min. After the reaction mixture was stirred for 30 min, aqueous sodium sulfite to the reaction mixture, which was then made acidic with 1N hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride and dried. The solvent was removed in vacuo. The residue was purified by silica gel column chromatography (hexane to hexane:ethyl acetate=1:2) to yield the entitled compound (665 mg) as an oil.

Provenance & Evidence