2,6-Pyridinedicarboxylic acid → HCID 18348594, compound

Participants

Reaction Steps

To a mixture of 4-benzyl-1-[8-(4,5,6,7-tetramethoxyindan-2-yl)octyl]piperazine (676 mg), 2,6-pyridinedicarboxylic acid (647 mg), THF (14 ml), and water (7 ml) was dropwise added a solution of CAN (2.83 g) in water (7 ml) with cooling with ice. After the reaction mixture was stirred for 15 min, saturated aqueous sodium bicarbonate was added to the reaction mixture, which was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium bicarbonate, water, and saturated aqueous sodium chloride and dried. The solvent was removed in vacuo. The residue was recrystallized from hexane-ethyl acetate to yield the entitled compound (380 mg) as crystals.

Provenance & Evidence