Tetrahydrofuran → HCID 18348675, compound

Participants

Reaction Steps

To a mixture of 1-[2-(1,2,3,4-tetramethoxy-6,7,8,9-tetrahydro-5H-benzo[a]cyclohepten-7-yl)ethyl]-1,2-dihydro-2-quinolinone (612 mg), pyridine-2,6-dicarboxylic acid (702 mg), THF (12 ml), and, water (6 ml) was added an water (6 ml) solution of CAN (3.07 g) with cooling with ice. After being stirred for 15 min, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was washed with water and saturated aqueous sodium chloride and dried. The solvent was removed in vacuo. The residue was purified by silica gel column chromatography(hexane to hexane:ethyl acetate=8:1) and then with recrystallization from hexane-ethyl acetate to obtain the entitled compound (310 mg).

Provenance & Evidence