Diethyl Ether → HCID 18349077, compound

Participants

Reaction Steps

A suspension of {3-methyl-5-[2-(pyridin-4-ylamino)-ethoxy]-phenyl}-methanol (0.132 g) and manganese dioxide (0.370 g) in 1,4-dioxan (5 ml) was heated to reflux with stirring under an atmosphere of dry nitrogen for 5 h. After cooling to room temperature the mixture was filtered through Harborlite® and the pad washed with 1,4-dioxan and then methanol. The combined filtrates were evaporated to dryness under reduced pressure to give an off-white solid. Trituration with diethyl ether gave, after drying, the title compound as a white powder (0.074 g).

Provenance & Evidence