HCID 18348926, compound → HCID 18349091, compound

Participants

Reaction Steps

A suspension of {3-bromo-5-[2-(pyridin-4-ylamino)-ethoxy]-phenyl}-methanol (1.4 g) and manganese dioxide (3.2 g) in 1,4-dioxan (50 ml) was heated to reflux with stirring under an atmosphere of dry nitrogen for 8 h. After cooling to room temperature the mixture was stirred at room temperature for 16 h, and then filtered through Harborlite® and the pad washed with hot methanol. The combined filtrates were evaporated to dryness under reduced pressure to give the title compound as an off-white solid (1.2 g).

Provenance & Evidence