Hydrochloric Acid → HCID 18348884, compound

Participants

Reaction Steps

2M Aqueous sodium hydroxide (0.33 ml) was added to a stirred solution of 4-({3-[2-(tert-butoxycarbonyl-pyridin-4-yl-amino)-ethoxy]-5-chloro-benzoyl}-cyclopentyl-amino)-butyric acid ethyl ester (0.189 g) in 1,4-dioxan (2 ml). 2M aqueous hydrochloric acid (0.33 ml) was added after 1 h. The reaction mixture was partitioned between ethyl acetate and water. The aqueous layer was removed and the organic phase was dried with brine and over sodium sulphate and then concentrated under reduced pressure to give the title compound (0.138 g) as a white foam.

Provenance & Evidence