反应详情

2M Aqueous sodium hydroxide (2.54 ml) was added to a stirred solution of 3-({3-[2-(tert-butoxycarbonyl-pyridin-4-yl-amino)-ethoxy]-5-chloro-benzoyl}-phenyl-amino)-propionic acid methyl ester (1.22 g) in 1,4-dioxan (15 ml). 2M Aqueous hydrochloric acid (2.54 ml) was added after 16 h. The reaction mixture was evaporated and the residue partitioned between ethyl acetate and water. The aqueous layer was removed and the organic phase was dried with brine and over sodium sulphate and then concentrated under reduced pressure to give the title compound (1.10 g) as a white foam.

1. customThe reaction mixture was evaporated
2. customthe residue partitioned between ethyl acetate and water
3. customThe aqueous layer was removed
4. dry with materialthe organic phase was dried with brine and over sodium sulphate
5. concentrationconcentrated under reduced pressure