HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline → HCID 69949644, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline | HCID 27833 | — |
| Reactant | Benzoic acid,3-chloro-5-[2-[[(1,1-dimethylethoxy)carbonyl]-4-pyridinylamino]ethoxy]- | HCID 18348849 | — |
| Reactant | HCID 18349129 | HCID 18349129 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 69949644 | HCID 69949644 | 38.9% |
Reaction Steps
A solution of 3-[2-(tert-butoxycarbonyl-pyridin-4-yl-amino)-ethoxy]-5-chloro-benzoic acid (0.040 g), cyclopentyl-(2-[1,2,4]triazol-1-yl-ethyl)-amine (0.05 g) and EEDQ (0.040 g) in acetonitrile (2 ml) was stirred at reflux, under nitrogen, for 2 h. The solvent was evaporated and the residue was purified by flash chromatography eluting with dichloromethane:methanol (95:5 v/v) to give the title compound as a yellow oil (0.022 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06326386B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-2b6ceb3b0241480d902b8b41b3cc0143 |
| Source note | uspto-grants-2001_12 |