HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline → HCID 69949070, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline | HCID 27833 | — |
| Reactant | Benzoic acid,3-chloro-5-[2-[[(1,1-dimethylethoxy)carbonyl]-4-pyridinylamino]ethoxy]- | HCID 18348849 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 69949070 | HCID 69949070 | 46.7% |
Reaction Steps
A solution of 3-[2-(tert-butoxycarbonyl-pyridin-4-yl-amino)-ethoxy]-5-chloro-benzoic acid (0.10 g) isopropyl-2-(pyridin-2-yloxy)-ethylamine (0.18 g) and EEDQ (0.136 g) in acetonitrile (2 ml) was stirred at reflux, under nitrogen, for 18 h. The solvent was evaporated and the residue was purified by flash chromatography on silica eluting with dichloromethane/methanol (98:2 then 96:4) to give the title compound as a pale yellow oil (0.033 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06326386B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-5bcb1c5151cf4a9bb9c79fac55ce8e2f |
| Source note | uspto-grants-2001_12 |