HuagongsheHuagongshe Chemistry Print Report · For research reference only
Neopentylamine → HCID 54401596, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Neopentylamine | HCID 79882 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 69950450 | HCID 69950450 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 54401596 | HCID 54401596 | — |
Reaction Steps
To a stirred solution of ({3-[2-(tert-butoxycarbonyl-pyridin-4-yl-amino)-ethoxy]-5-chloro-benzoyl}-cyclobutyl-amino)-propionic acid (0.025 g) and HATU® (0.038 g) in DMF (1 ml) was added DIPEA (0.017 ml) followed by neopentylamine (0.053 ml) after 10 min. The reaction mixture was stirred at room temperature for 18 h and then concentrated under reduced pressure. The residue was subjected to preparative hplc and the title compound (0.016 g) was obtained as a colourless gum by concentration of the required fraction under reduced pressure and drying by repetitive addition of acetonitrile and concentration under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06326386B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-fa274a6cfb7343c3a104ba8d43b6ea39 |
| Source note | uspto-grants-2001_12 |