Trifluoroacetic acid methylene chloride → HCID 18349106, compound

HRID 2268675Notes

Reaction equation

HRID 2268675 reaction equation
C(OC(=O)[N:7]([CH2:14][CH2:15][O:16][C:17]1[CH:22]=[C:21]([C:23](=[O:38])[N:24]([CH2:28][CH2:29][CH2:30][NH:31][C:32](=[O:37])[C:33]([CH3:36])([CH3:35])[CH3:34])[CH:25]([CH3:27])[CH3:26])[CH:20]=[C:19]([Cl:39])[CH:18]=1)[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)(C)(C)C.ClCCl.[F:44][C:45]([F:50])([F:49])[C:46]([OH:48])=[O:47]>ClCCl>[F:44][C:45]([F:50])([F:49])[C:46]([OH:48])=[O:47].[Cl:39][C:19]1[CH:20]=[C:21]([CH:22]=[C:17]([O:16][CH2:15][CH2:14][NH:7][C:8]2[CH:9]=[CH:10][N:11]=[CH:12][CH:13]=2)[CH:18]=1)[C:23]([N:24]([CH2:28][CH2:29][CH2:30][NH:31][C:32](=[O:37])[C:33]([CH3:36])([CH3:35])[CH3:34])[CH:25]([CH3:26])[CH3:27])=[O:38]

Participants

4

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 69948091HCID 69948091, compound

Product 1

HCID 18349106HCID 18349106, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of [2-(3-chloro-5-{[3-(2,2-dimethyl-propionylamino)-propyl]-isopropyl-carbamoyl}-phenoxy)-ethyl]-pyridine-4-yl-carbamic acid tert-butyl ester in dichloromethane (1 ml) was treated with dichloromethane:trifluoroacetic acid (1:1 v/v) (1 ml), stirred for 3 h at room temperature and concentrated under reduced pressure. The residue was subjected to preparative hplc to give the title compound (0.039 g) as an oil.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-ce55d571d61140ff8e65555d0d353ed0
Source dataset
uspto-grants-2001_12
Patent number
US06326386B1

Reaction notes

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