Dichlorodimethylsilane → HCID 18332209, compound

HRID 2268722Notes

Reaction equation

HRID 2268722 reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[C:4]([F:10])[C:3]=1[OH:11].C([Li])CCC.[Cl:17][Si:18](Cl)([CH3:20])[CH3:19]>C1(C)C=CC=CC=1>[F:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[C:4]([F:10])[C:3]=1[O:11][Si:18]([Cl:17])([CH3:20])[CH3:19]

Participants

5

Reactant 3

HCID 6398DichlorodimethylsilaneHCID 698582,3,5,6-TetrafluorophenolHCID 178418339Butyllithium

Product 1

HCID 18332209HCID 18332209, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

3.32 g (20 mmol) of 2,3,5,6-tetrafluorophenol are dissolved in 50 ml of toluene, and 8 ml of n-butyllithium (2.5 M in hexane) are added at 0° C. After warming to room temperature, the solution is stirred for 2 hours. Then 2.6 g of dichlorodimethylsilane (20 mmol) are added dropwise. The resulting suspension is filtered and the solvent is stripped off in vacuo. The colorless liquid which remains is subjected to fractional distillation.

Workup

  1. filtrationThe resulting suspension is filtered
  2. distillationThe colorless liquid which remains is subjected to fractional distillation

Sources & evidence

ORD record
ord-8be9c565853a4dc89fb11044ff7a43e5
Source dataset
uspto-grants-2001_12
Patent number
US06329313B1

Reaction notes

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