6-fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole → 6-fluoro-3-(piperidin-4-yl)-1H-indole

Participants

Reaction Steps

A mixture of platinum oxide (1.0 g) in ethanol (37.5 ml) and glacial acetic acid (12.5 ml) were mixed under nitrogen with 6-fluoro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (20 g, 0.0926 mol) in ethanol (187.5 ml) and glacial acetic acid (62.5 ml). The reaction mixture was then hydrogenated at 60 psi until the reaction was complete by tlc. The catalyst was removed by fitration and the solvent evaporated in vacuo to give a yellow solid which was dried at 60° C. in vacuo (EP 722941).

Provenance & Evidence