4-Acetyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid → HCID 70248916, compound

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Reaction Steps

from O-(2,6-dichlorobenzyl)-L-tyrosine methyl ester hydrochloride and 3,5-dimethyl-4-acetylpyrrole-2-carboxylic acid. Freeze drying afforded the title compound as a light cream amorphous solid (550 mg). δH (DMSO-d6) 11.56, (1H, s), 7.61 (1H, d, J 7.8 Hz), 7.51 (2H, d, J 8.0 Hz), 7.41 (1H, t, J 8.0 Hz), 7.21 (2H, d, J 85 Hz), 6.96 (2H, d, J 8.5 Hz), 5.16 (2H, s), 4.69-4.55 (1H, m), 3.12 (1H, dd, J 13.7, 4.7 Hz), 2.99 (1H, dd, J 13.7, 9.1 Hz), 2.43 (3H, s), 2.38 (3H, s), 2.31 (3H, s); m/z (ESI, 60V) 503 (MH+).

Provenance & Evidence