2-Methylnicotinic acid → HCID 70144199, compound

HRID 2268808Notes

Reaction equation

HRID 2268808 reaction equation
Cl.C[O:3][C:4](=[O:24])[C@H:5]([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]2[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:23])=[CH:10][CH:9]=1)[NH2:6].[CH3:25][C:26]1[N:34]=[CH:33][CH:32]=[CH:31][C:27]=1[C:28](O)=[O:29]>>[CH3:25][C:26]1[N:34]=[CH:33][CH:32]=[CH:31][C:27]=1[C:28]([NH:6][C@H:5]([C:4]([OH:3])=[O:24])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]2[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:23])=[CH:10][CH:9]=1)=[O:29]

Participants

3

Reactant 2

HCID 6433732-Methylnicotinic acidHCID 69806827HCID 69806827, compound

Product 1

HCID 70144199HCID 70144199, compound

Procedure

from O-(2,6-dichlorobenzyl)-L-tyrosine methyl ester hydrochloride and 2-methylnicotinic acid. δH (DMSO-d6) 8.73 (1H, br d), 8.48 (1H, m), 7.7-7.46 (4H, m), 7.4-7.23 (3H, m), 7.00 (2H, d, J 8.4 Hz), 5.2) (2H, s), 4.60 91H, m), 3.27-3.12 (1H, m), 3.0-2.82 (1H, m); m/z (ESI, 60V) 509 (MH+).

Sources & evidence

ORD record
ord-4294b59f2410493ca4a8c3f38cd83f8e
Source dataset
uspto-grants-2001_12
Patent number
US06329372B1

Reaction notes

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