HCID 69806827, compound → HCID 178523860, compound

HRID 2268811Notes

Reaction equation

HRID 2268811 reaction equation
Cl.C[O:3][C:4](=[O:24])[C@H:5]([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]2[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:23])=[CH:10][CH:9]=1)[NH2:6].[OH:25][C:26]1[N:34]=[CH:33][CH:32]=[CH:31][C:27]=1[C:28](O)=[O:29]>>[OH:25][C:26]1[N:34]=[CH:33][CH:32]=[CH:31][C:27]=1[C:28]([NH:6][C@H:5]([C:4]([OH:3])=[O:24])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]2[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:23])=[CH:10][CH:9]=1)=[O:29]

Participants

3

Reactant 2

HCID 69806827HCID 69806827, compoundHCID 178418543HCID 178418543, compound

Product 1

HCID 178523860HCID 178523860, compound

Procedure

from O-(2,6-dichlorobenzyl)-L-tyrosine methyl ester hydrochloride and 2-hydroxynicotinic acid. δH (DMSO-d6) 10.15 (1H, d, J 7.4 Hz), 8.31 (1H, dd, J 7.1, 2.0 Hz), 7.71 (1H, br s), 7.65-7.45 (3H, m), 7.16 (2H, d, J 8.4 Hz), 6.97 (2H, d, J 8.4 Hz), 6.46 (1H, t, J 6.8 Hz), 5.17 (2H, s), 4.68 (1H, m), 3.2-3.0 (2H, m); m/z (ESI, 60V) 461 (MH+).

Sources & evidence

ORD record
ord-94870016aaca4109ac9efe9047e146bb
Source dataset
uspto-grants-2001_12
Patent number
US06329372B1

Reaction notes

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