Ethanol → HCID 178470710, compound

Participants

Reaction Steps

A solution of (2) (0.935 g, 2.86 mmol) in ethanol (20 mL) and concentrated H2SO4 (3.5 mL) was heated at reflux for 24 h. The ethanol was evaporated in vacuo, cold water (30 mL) was added and the solution was then neutralised with NaOH 10M. The mixture was extracted with CHCl3 (4×20 ml,) and the combined organic phases were dried (MgSO4) and evaporated in vacuo. The resulting residue was triturated with ethanol and filtered to give 0.190 g (19%) of 2-[(5,6-Dimetlhyl-2-benzoimidazolyl)amino]-4-hydroxy-6-methyl-5-pyrimidine acetic acid, ethyl ester (1). mp: >300° C. (CF3CO2H/C2H5OH). IR (KBr): υ=3254, 2968, 2922, 1737, 1623, 1560, 1344, 1294, 774 cm−1. Accurate mass: calculated: 355.1644. Found 327.1644. Analysis calculated for C18H21N5O3: C, 60.83; H, 5.96; N, 19.71. Found: C, 60.1; H, 5.7; N, 18.7.

Provenance & Evidence