2-chloro-5-fluoro-N-(3-hydroxyphenyl)-4-pyrimidineamine → HCID 22060338, compound

HRID 226884Notes

Reaction equation

HRID 226884 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([OH:15])[CH:10]=2)[C:5]([F:16])=[CH:4][N:3]=1.[CH2:17]([NH:19][C:20]([O:22][C:23]1[CH:24]=[C:25]([CH:27]=[CH:28][CH:29]=1)[NH2:26])=[O:21])[CH3:18]>>[CH2:17]([NH:19][C:20]([O:22][C:23]1[CH:24]=[C:25]([NH:26][C:2]2[N:7]=[C:6]([NH:8][C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([OH:15])[CH:10]=3)[C:5]([F:16])=[CH:4][N:3]=2)[CH:27]=[CH:28][CH:29]=1)=[O:21])[CH3:18]

Participants

3

Reactant 2

HCID 220604512-chloro-5-fluoro-N-(3-hydroxyphenyl)-4-pyrimidineamineHCID 22060978HCID 22060978, compound

Product 1

HCID 22060338HCID 22060338, compound

Procedure

In like manner to the preparation of 5-fluoro-N4-(3-hydroxyphenyl)-N2-[4-(3-phenyl-1,2,4-oxadiazol-5-yl)methyleneoxyphenyl]-2,4-pyrimidinediamine, 2-chloro-5-fluoro-N4-(3-hydroxyphenyl)-4-pyrimidineamine and 3-[(N-ethylamino)carbonyloxy]aniline were reacted to provide N2-[3-[(N-ethylamino)carbonyloxy]phenyl]-5-fluoro-N4-(3-hydroxyphenyl)-2,4-pyrimidinediamine.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-6dbb9bba14ac490a99e654b1943e4638
Source dataset
uspto-grants-2009_07
Patent number
US07557210B2

Reaction notes

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