Ethanol → 3-Benzyloxy-4-methoxybenzaldehyde

Participants

Reaction Steps

A mixture of 3-hydroxy-4-methoxy-benzaldehyde (100 g, 0.657 mole), ethanol (300 ml), K2CO3 (108.9 g, 0.788 mole), benzyl chloride (86.8 ml, 0.755 mole) and NaI (5 g) under N2 was refluxed under stirring for 2.5 hours, then cooled and added with water (900 ml). The precipitate was filtered, washed with water, and then with petrolatum, then dried under vacuum at 40° C. to give 159 g of the title compound which was used as such in the subsequent step.

Provenance & Evidence