反应详情

A solution of 3,4-dihydroxy-5-methoxy-3H-isobenzofuran-1-one (6.63 g, 34 mmoles), prepared as described in example 57, in ethanol (60 ml) was added with 98% hydrazine (8.5 ml). The mixture was heated to clarity and after 5 minutes a precipitate formed and was filtered and treated with 1N HCl. The mother liquors were concentrated more times and the resultant solid fractions joined to give 4.65 g of the title compound (yield: 72%).

1. temperatureThe mixture was heated to clarity and after 5 minutes a precipitate
2. customformed
3. filtrationwas filtered
4. additiontreated with 1N HCl
5. concentrationThe mother liquors were concentrated more times