Water → HCID 18381656, compound

Participants

Reaction Conditions

Reaction Steps

A mixture under N2 of trifluoro-methanesulfonic acid 6-methoxy-1-oxo-1,2-dihydro-phthalazin-5-yl ester (2 g, 6.16 mmoles), prepared as described in example 59, pent-4-ynyl-benzene (1.33 g, 9.24 mmoles), bis(triphenylphosphine)PdCl2 (216 mg, 0.308 mmole) and triethylamine (3.42 ml, 24.64 mmoles) in DMF (40 ml) was heated to 90° C. for 3 hours, then poured into water (200 ml), filtered and the precipitate was washed with water to give 1.28 g of the title compound (yield: 65%).

Provenance & Evidence