Phosphorus oxychloride → HCID 18381670, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 6-methoxy-5-(5-phenyl-pent-1-ynyl)-2H-phthalazin-1-one (1.26 g, 3.96 mmoles), prepared as described in example 64, and POCl3 (30 ml) was heated at 80° C. under stirring up to dissolution. After 30 minutes the solution was brought to dryness, the residue dissolved in CH2Cl2, washed to alkalinity with a diluted solution of K2CO3, then with water, anhydrified over Na2SO4 and brought to dryness to give 1.33 g of the title compound (quantitative yield). The compound was used as such in the subsequent step.

Provenance & Evidence