Water → 1-(3,5-Dichloro-pyridin-4-ylmethyl)-6-difluoromethoxy-4-morpholin-4-yl-phthalazine

Participants

Reaction Conditions

Reaction Steps

A suspension under N2 of 4-chloro-1-(3,5-dichloro-pyridin-4-ylmethyl)-6-difluoromethoxy-phthalazine (5.5 g, 14.1 mmoles), prepared as described in example 99, in morpholine (11 ml) was heated at 100° C. for 1 hour, then cooled and poured into water (150 ml). A solid formed and was stirred for 15 minutes, then filtered, washed with water, dried over P2O5 at 50° C. under high vacuum. There were obtained 6 g of the title compound (yield: 96%). m.p.: 128.6-130.6° C.

Provenance & Evidence