Sodium Hydroxide → HCID 18381658, compound

HRID 2268917Notes

Reaction equation

HRID 2268917 reaction equation
C[O:2][C:3](=[O:24])[CH2:4][CH2:5][CH2:6][C:7]1[C:16]2[C:11](=[CH:12][C:13]([O:17][CH3:18])=[CH:14][CH:15]=2)[C:10]([C:19]2[S:20][CH:21]=[CH:22][N:23]=2)=[N:9][N:8]=1.[OH-].[Na+]>CO>[CH3:18][O:17][C:13]1[CH:12]=[C:11]2[C:16](=[CH:15][CH:14]=1)[C:7]([CH2:6][CH2:5][CH2:4][C:3]([OH:24])=[O:2])=[N:8][N:9]=[C:10]2[C:19]1[S:20][CH:21]=[CH:22][N:23]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 543700044-(6-Methoxy-4-thiazol-2-yl-phthalazin-1-yl)-butyric acid methyl ester

Product 1

HCID 18381658HCID 18381658, compoundYield 82.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-(6-Methoxy-4-thiazol-2-yl-phthalazin-1-yl)-butyric acid methyl ester (1.2 g, 3.5 mmoles), prepared as described in example 115, was dissolved in warm CH3OH (30 ml) and added with 10% NaOH (2.8 ml, 7 mmoles), then refluxed. After 30 minutes the mixture was cooled, dried, taken up in water and extracted with CH2Cl2. The aqueous phase was discoloured with charcoal and acidified with acetic acid. The precipitate was filtered, washed with water and dried to give 0.95 g of the title compound (yield: 82.4%). m.p.: 218-220° C.

Workup

  1. temperaturerefluxed
  2. temperatureAfter 30 minutes the mixture was cooled
  3. customdried
  4. extractionextracted with CH2Cl2
  5. filtrationThe precipitate was filtered
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-aef8a179a5ef4565bbf8488eea92cb83
Source dataset
uspto-grants-2001_12
Patent number
US06329370B1

Reaction notes

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