Hydrochloric Acid → HCID 18381652, compound

Participants

Reaction Steps

A suspension of 6-methoxy-5-trimethylsilanylethynyl-2H-phthalazin-1-one (2.87 g, 10.20 mmoles), prepared as described in example 139, in acetonitrile (50 ml) was added with 32% NaOH (15 ml) and stirred at room temperature for 1 hour. The mixture was neutralised with concentrated HCl and the precipitate filtered off. The aqueous phase was extracted with ethyl acetate, the organic phase was dried and taken up in acetone. The solid was filtered off and joined to the previous precipitate to give 1.99 g of the title compound (yield: 97.3%).

Provenance & Evidence