HCID 9803404, compound → HCID 9948553, compound

HRID 2268969Notes

Reaction equation

HRID 2268969 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([CH2:17][NH:18][C:19]2[N:24]=[C:23]([N:25]3[C:29]4[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=4[N:27]=[CH:26]3)[CH:22]=[CH:21][N:20]=2)[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>CC#N>[NH:11]1[CH2:16][CH2:15][CH:14]([CH2:17][NH:18][C:19]2[N:24]=[C:23]([N:25]3[C:29]4[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=4[N:27]=[CH:26]3)[CH:22]=[CH:21][N:20]=2)[CH2:13][CH2:12]1

Participants

3

Reactant 1

HCID 9803404HCID 9803404, compound

Product 1

HCID 9948553HCID 9948553, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound was prepared according to the procedure described in EXAMPLE 18 starting with 2-[1-(1-benzyloxycarbonylpiperidin-4-yl)methyl-amino]-4-[benzimidazol-1-yl]pyrimidine. Partial 1H NMR (500 M, CDCl3): δ 8.59 (s, 1H); 8.33 (br s, 1H); 8.16 (br s, 1H); 7.82 (d, J=7.8 Hz, 1H); 7.34 m, 2H); 6.73 (d, J=5.5 Hz, 1H); 3.37 (dd, J=6.2, 5.9 Hz, 2H); 3.09 (d, J=11.9 Hz, 2H); 2.58 (t, J=11.9 Hz, 2H); 1.79 (d, J=10.7 Hz, 3H); 1.23 (m, 2H). Mass spectrum 350.1 (ESI, M+CH3CN+1).

Sources & evidence

ORD record
ord-b8b63d24a2ef4dbe845c07c93a02255e
Source dataset
uspto-grants-2001_12
Patent number
US06329380B1

Reaction notes

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