HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(1-Aminoethyl)-1-(benzyloxycarbonyl)piperidine → 2-[1-(1-Benzyloxycarbonylpiperidin-3-yl)ethylamino]-4-[5-(pyridin-4-yl)benzimidazol-1-yl]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(1-Aminoethyl)-1-(benzyloxycarbonyl)piperidine | HCID 15550583 | — |
| Reactant | 2-Hexanesulfonyl-4-[5-(pyridin-4-yl)benzimidazol-1-yl]pyrimidine | HCID 18375831 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-[1-(1-Benzyloxycarbonylpiperidin-3-yl)ethylamino]-4-[5-(pyridin-4-yl)benzimidazol-1-yl]pyrimidine | HCID 18332617 | — |
Reaction Steps
The title compound was prepared from 2-hexanesulfonyl-4-[5-(pyridin-4-yl)-benzimidazol-1-yl]pyrimidine and 2-hexanesulfoxide-4-[5-(pyridin-4-yl)-benzimidazol-1-yl]pyrimidine 1:1 mixture and 3-(1-aminoethyl)-1-(benzyloxy-carbonyl)piperidine according to the procedure described in EXAMPLE 17 using DMSO instead of toluene as solvent. Mass spectrum (ESI) 534.4 (M+1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329380B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-97df9240714142459aa93abb14582ee4 |
| Source note | uspto-grants-2001_12 |