alpha-Naphthyl isocyanate → 2-[1-(1-(N-(Naphth-1-yl)carbamoyl)piperidin-3-yl)ethylamino]-4-[5-(pyridin-4-yl)-benzimidazol-1-yl]pyrimidine

HRID 2268976Notes

Reaction equation

HRID 2268976 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH:3]([CH:7]([NH:9][C:10]2[N:15]=[C:14]([N:16]3[C:20]4[CH:21]=[CH:22][C:23]([C:25]5[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=5)=[CH:24][C:19]=4[N:18]=[CH:17]3)[CH:13]=[CH:12][N:11]=2)[CH3:8])[CH2:2]1.[C:31]1([N:41]=[C:42]=[O:43])[C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[CH:34]=[CH:33][CH:32]=1>>[C:31]1([NH:41][C:42]([N:1]2[CH2:6][CH2:5][CH2:4][CH:3]([CH:7]([NH:9][C:10]3[N:15]=[C:14]([N:16]4[C:20]5[CH:21]=[CH:22][C:23]([C:25]6[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=6)=[CH:24][C:19]=5[N:18]=[CH:17]4)[CH:13]=[CH:12][N:11]=3)[CH3:8])[CH2:2]2)=[O:43])[C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[CH:34]=[CH:33][CH:32]=1

Participants

3

Reactant 2

HCID 66589alpha-Naphthyl isocyanateHCID 183326202-[1-(Piperidin-3-yl)-ethylamino]-4-[5-(pyridin-4-yl)-benzimidazol-1-yl]pyrimidine

Product 1

HCID 183326252-[1-(1-(N-(Naphth-1-yl)carbamoyl)piperidin-3-yl)ethylamino]-4-[5-(pyridin-4-yl)-benzimidazol-1-yl]pyrimidine

Procedure

The title compound was prepared from 2-[1-(piperidin-3-yl)-ethylamino]-4-[5-(pyridin-4-yl)-benzimidazol-1-yl]pyrimidine according to the procedure described in EXAMPLE 29 using 1-naphthylisocyanate. Mass spectrum (ESI) 569.5 (M+1).

Sources & evidence

ORD record
ord-632076db3aee468aadc3d56511f8e3fc
Source dataset
uspto-grants-2001_12
Patent number
US06329380B1

Reaction notes

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