Ammonia → HCID 178509025, compound

Participants

Reaction Steps

6-Amino-9-benzyl-8-bromo-2-(2-naphthylthio)purine (33 mg, 0.043 mmol) in a mixture of concentrated hydrochloric acid (20 ml) and dimethyl sulfoxide (7 ml) was refluxed for 6 hours under heating. The reaction mixture was made basic with 28% aqueous ammonia, and the resulting crystals were filtered, washed with water and the crude product was purified by thin-layer chromatography to give the subject compound (6 mg, yield 35%).

Provenance & Evidence