1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- → HCID 178509051, compound

Participants

Reaction Steps

6-Amino-9-benzyl-8-hydroxy-2-mercaptopurine (120 mg, 0.44 mmol) was suspended in dimethylformamide (10 ml). To the suspension were added potassium carbonate (60 mg, 0.43 mmol) and 2-phthalimidoethyl bromide (112 mg, 0.44 mmol) in order. The mixture was stirred at room temperature for 2 hours. The solvent was removed in vacuo and to the residue was added saturated brine. The mixture was extracted with ethyl acetate, the organic layer was dried on magnesium sulfate, and the solvent was removed in vacuo. Methanol was added to the residue, and the resulting crystals were taken by filtration to give the subject compound (107 mg, yield 54%).

Provenance & Evidence