Potassium Carbonate → HCID 178509047, compound

Participants

Reaction Steps

Crude 6-amino-9-benzyl-8-hydroxy-2-mercaptopurine (200 mg, 0.73 mmol) was suspended in dimethylformamide (100 ml). To the suspension were added potassium carbonate (150 mg, 1.1 mmol) and 3-bromo-1-propanol (0.1 ml, 1 mmol) in order. The mixture was stirred at room temperature for 4 hours. The solvent was removed in vacuo, and the residue was purified by silica gel chromatography (1% methanol/chloroform) to give the subject compound (149 mg, yield 62%).

Provenance & Evidence