Chloromethyl Methyl Ether → HCID 178502589, compound

Participants

Reaction Steps

Crude 6-amino-9-benzyl-8-hydroxy-2-mercaptopurine (134 mg, 0.49 mmol) was suspended in dimethylformamide (65 ml). To the suspension were added potassium carbonate (100 mg, 0.72 mmol) and chloromethyl methyl ether (0.056 ml, 0.73 mmol) in order. The mixture was stirred at room temperature for 2 hours. The solvent was removed in vacuo, and the residue was purified by silica gel chromatography (2% methanol/chloroform) to give the subject compound (107 mg, yield 69%).

Provenance & Evidence