2-Chloro-N,N-dimethylethylamine → HCID 178483977, compound

Participants

Reaction Steps

Crude 6-amino-9-benzyl-8-hydroxy-2-mercaptopurine (200 mg, 0.73 mmol) was suspended in dimethylformamide (80 ml). To the suspension were added potassium carbonate (300 mg, 2.2 mmol) and 2-dimethylaminoethylchloride (160 mg, 1.1 mmol) in order. The mixture was stirred at room temperature for 11 hours. The solvent was removed in vacuo, and the residue was purified by silica gel chromatography (10% methanol/chloroform) to give the subject compound (9 mg, yield 4%).

Provenance & Evidence