Sodium Bicarbonate → 6-Amino-9-benzyl-8-hydroxy-2-(formylmethylthio)purine

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

6-Amino-9-benzyl-2-(1,3-dioxolan-2-yl-methyl)thio-8-hydroxypurine (44 mg, 0.12 mmol) was dissolved in a mixture of 3.3N hydrochloric acid (1 ml) and tetrahydrofuran (4 ml). The solution was stirred at 70° C. for 7 hours and then neutralized with aqueous sodium hydrogen carbonate. After removal of tetrahydrofuran in vacuo, the resulting crystals were filtered, washed with water and repulped in methanol to give the subject compound (17 mg, yield 44%).

Herkunft & Nachweise