Sodium Bicarbonate → HCID 178509046, compound

Participants

Reaction Conditions

Reaction Steps

6-Amino-9-benzyl-2-[2-(1,3-dioxolan-2-yl)ethyl)thio-8-hydroxypurine (74 mg, 0.20 mmol) was dissolved in a mixture of 3.3N hydrochloric acid (1 ml) and tetrahydrofuran (4 ml). The solution was stirred at 70° C. for 7 hours and then neutralized with aqueous sodium hydrogen carbonate. After removal of tetrahydrofuran in vacuo, the resulting crystals were filtered, purified by silica gel chromatography (5% methanol/chloroform) to give the subject compound (17 mg, yield 44%).

Provenance & Evidence