Potassium Carbonate → HCID 18332740, compound

Participants

Reaction Steps

Crude 6-amino-9-benzyl-8-hydroxy-2-mercaptopurine (134 mg, 0.49 mmol) was suspended in dimethylformamide (60 ml). To the suspension were added potassium carbonate (200 mg, 1.44 mmol) and 3-dimethylaminopropyl chloride hydrochloride (114 mg, 0.72 mmol) in order. The mixture was stirred at room temperature for 9 hours. The solvent was removed in vacuo, and the residue was purified by silica gel chromatography (14% methanol/chloroform) to give the subject compound (13 mg, yield 7%).

Provenance & Evidence