Potassium Carbonate → HCID 178509047, compound

Participants

Reaction Steps

Crude 6-amino-9-benzyl-8-hydroxy-2-mercaptopurine (134 mg, 0.49 mmol) was suspended in dimethylformamide (60 ml). To the suspension were added potassium carbonate (100 mg, 0.72 mmol) and 3-bromo-1-propanol (0.07 ml, 0.7 mmol) in order. The mixture was stirred at room temperature for 3 hours. The solvent was removed in vacuo, and the residue was purified by silica gel chromatography (4% methanol/chloroform) to give the subject compound (64 mg, yield 39%).

Provenance & Evidence