Chloroacetonitrile → HCID 178511465, compound

Participants

Reaction Steps

Crude 6-amino-9-benzyl-8-hydroxy-2-mercaptopurine (150 mg, 0.55 mmol) was suspended in dimethylformamide (10 ml). To the suspension were added potassium carbonate (81 mg, 0.59 mmol) and chloroacetonitrile (44 mg, 0.59 mmol) in order. The mixture was stirred at room temperature for 3 hours. The solvent was removed in vacuo, and to the residue was added water. The mixture was extracted with chloroform and the organic layer was dried on sodium sulfate. After removal of the solvent in vacuo, the residue was purified by silica gel chromatography (1% ammonia, 5% methanol/chloroform) to give the subject compound (58 mg, yield 25%).

Provenance & Evidence