Potassium Carbonate → HCID 178509052, compound

Participants

Reaction Steps

Crude 6-amino-9-benzyl-8-hydroxy-2-mercaptopurine (470 mg, 1.7 mmol) was suspended in dimethylformamide (100 ml). To the suspension were added potassium carbonate (350 mg, 2.5 mmol) and 2-(2-chloroethoxy)ethanol (0.27 ml, 2.6 mmol) in order. The mixture was stirred at room temperature for 4 hours. The solvent was removed in vacuo and the residue was purified by silica gel chromatography (7% methanol/chloroform) to give the subject compound (159 mg, yield 27%).

Provenance & Evidence