Potassium Carbonate → HCID 178467874, compound

Participants

Reaction Steps

Crude 6-amino-9-benzyl-8-hydroxy-2-mercaptopurine (80 mg, 0.65 mmol) was suspended in dimethylformamide (60 ml). To the suspension were added potassium carbonate (150 mg, 1.1 mmol) and 2-ethoxypropyl p-toluenesulfonate (280 mg, 1.1 mmol) in order. The mixture was stirred at room temperature for 4 hours. The solvent was removed in vacuo, and the residue was purified by silica gel chromatography (5% methanol/chloroform) to give the subject compound (69 mg, yield 30%).

Provenance & Evidence