HCID 178509051, compound → HCID 178511466, compound

Participants

Reaction Steps

6-Amino-9-benzyl-8-hydroxy-2-(2-phthalimidoethylthio)purine (78 mg, 0.18 mmol) was suspended in 1M hydrazine monohydrate (10 ml). The suspension was stirred at room temperature for 9 hours. The reaction mixture was evaporated in vacuo to dryness and to the residue was added 2N hydrochloric acid. Insoluble materials were filtered off and the filtrate was neutralized with 28% aqueous ammonia and extracted with ethyl acetate. The organic layer was dried on magnesium sulfate and evaporated in vacuo to dryness to give the subject compound (4 mg, yield 7%).

Provenance & Evidence